Therapeutic Potential of Prodrugs Towards Targeted Drug Delivery

Liver-targeted drug delivery using HepDirect prodrugs.

Targeting drugs to specific organs, tissues, or cells is an attractive strategy for enhancing drug efficacy and reducing side effects. Drug carriers such as antibodies, natural and manmade polymers, and labeled liposomes are capable of targeting drugs to blood vessels of individual tissues but often fail to deliver drugs to extravascular sites. An alternative strategy is to use low molecular we...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery

Sn2 lipase labile phospholipid prodrugs in conjunction with contact-facilitated drug delivery offer an important advancement in Nanomedicine. Many drugs incorporated into nanosystems, targeted or not, are substantially lost during circulation to the target. However, favorably altering the pharmacokinetics and volume of distribution of systemic drug delivery can offer greater efficacy with lower...

Ovel Therapeutic Applicatio of Microbubbles for Targeted Drug Delivery

Blood-brain barrier impermeability presents a problem while treating malignant and degenerative disorders of the central nervous system, such as brain cancer, Alzheimer's and Parkinson's disease. The protective blood-brain barrier blocks many drugs from acting on brain cells. A method for delivering drugs directly to the affected area may increase the effectiveness of chemotherapy in brain tumo...